Kawasaki disease is an acute, self-limited, multisystem vasculitis with unknown etiology diagnosed clinically in children with fever. In addition, children with Kawasaki disease, with or without coronary artery complications, may have a more adverse cardiovascular risk profile, such as high blood pressure, obesity, and abnormal serum lipid profile. Medicine (Baltimore) 2010; 89:149. A number of theories link the disease to bacteria, viruses or other environmental factors, but none has been proved. Some now believe that many factors (viruses, staphylococci "super antigens") are capable of triggering a final common pathway that results in immune activation. What has been confirmed is that specific genes may make a child more likely to suffer a Kawasaki disease. The early age of onset for Kawasaki disease suggests that pre- and perinatal exposures may be risk factors, including maternal autoimmune disorders that may share immune pathways with the disease. No one knows what causes Kawasaki disease, but scientists don’t believe it is contagious. 2 … Published online Jan 2009 Risk factors for Kawasaki disease-associated coronary abnormalities differ depending on age DooIl Song et.al; Risk factors for Kawasaki disease-associated coronary abnormalities differ depending on age. Risk Factors Associated With Kawasaki Disease. Kawasaki disease (KD) is an acute vasculitis that preferentially affects medium‐sized arteries, particularly the coronary arteries (CA).1, 2, 3 CA involvement can range from transient mild dilatation or ectasia, occurring in up to 40% of patients, to giant coronary artery aneurysms (CAA).4, 5 In the pre–intravenous immunoglobulin (IVIG) era, CAA occurred in 20% to 25% of KD patients.6 With IVIG therapy, persistent CAAs are considerably less common but still occur in 4% to 6% of patients, with ≈1% developing giant C… In this retrospective case-control study, children with KDSS admitted to the intensive care unit from 2007 to 2017 were identified and compared with age-matched controls with septic shock. The risk factors that make an individual vulnerable to the disease are: Age. Outbreaks of the disease are more common during the winter and early spring months. However, no infectious agent (such as a virus or bacteria) has been identified. An Study design. Design Retrospective cohort study using data from the nationwide KD survey in Japan. Kawasaki Disease Risk Factors Previous studies have shown that children with Kawasaki disease (KD) who fail to respond to intravenous immunoglobulin (IVIG) therapy are at higher risk of developing coronary artery lesions (CALs). Acta Paediatr 2001; 90:40. Hirata S, Nakamura Y, Yanagawa H. Incidence rate of recurrent Kawasaki disease and related risk factors: from the results of nationwide surveys of Kawasaki disease in Japan. Eur J Pediatr DOI 10.1007/s00431-009-0925-0. We aimed to conduct a meta-analysis to uncover the risk factors associated with IVIG resistance in children with KD. What are the Risk Factors for Kawasaki Disease? Risk Factors. Other risk factors include being a male gender, being between six months … However, 25% of cases involve infants younger than one and over the age of five. Coronary artery aneurysm in Kawasaki disease: risk factors for progressive disease and adverse cardiac events in US population. Early symptoms in the first 2 weeks may include: Risk Factors. Friedman KG, Gauvreau K, Hamaoka-Okamoto A, et al. Kawasaki disease is more among children under five years of age. To compare the clinical features and resuscitative measures of children with Kawasaki disease shock syndrome versus septic shock. Kawasaki Disease Risk Factors. Independent predictors of greater number of illness days at diagnosis included center, age of <6 months, incomplete Kawasaki disease, and greater distance from the center. The factors causing the onset of this disease still remain unknown, though a number of risk factors have been identified. A variation in the ITPKC gene has been associated with an increased risk of Kawasaki disease. In some patients, an association has been noted between elevated liver enzymes or an abnormal gallbladder (GB) and hepatobiliary involvement in KD. Because cases of the disorder tend to cluster geographically and by season, researchers have suggested that an infection may be involved. Ages six months to five years are more vulnerable than children in other age groups. Independent predictors of greater number of illness days at diagnosis included center, age of <6 months, incomplete Kawasaki disease, and greater distance from the center. Gomard-Mennesson E, Landron C, Dauphin C, et al. Some people are more at risk of developing the issue compared to others. Risk Factors.   Other risk factors: Sex may play a role who gets Kawasaki disease, as boys are slightly more likely to be affected. Risk factors. Centers differed in the patient percentage with incomplete Kawasaki disease; clinical criteria of cervical adenopathy, oral changes, and conjunctivitis; and distance of residence from the center. RESULTS: Patients and control subjects were similar in age, sex, body mass index,waist-to-hip ratio, blood pressure, cigarette smoking, family history, diet,high-density lipoprotein cholesterol level, lipoprotein (a) level, homocysteinelevel, glucose level, insulin level, CIMT, arterial stiffness, C-reactive proteinlevel, and inflammatory cytokine level. Kawasaki disease (KD) is an acute febrile vasculitis that causes coronary artery abnormality (CAA) as a complication. Having a risk factor for Kawasaki disease makes the chances of getting a condition higher but does not always lead to Kawasaki disease.
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