The induction of dominant lethal mutations in CD rats by m‐phenylenediamine was studied in a group of 20 male animals given doses of 20 mg/kg body weight by intraperitoneal injection, 3 times weekly for 8 weeks (presumably 20 mg/kg per injection; method description unclear). The metabolites excreted by the rat liver perfused with 0.25 or 0.5 mM 14C‐m‐phenylenediamine were the same as those found in the urine. The odor threshold for p-phenylenediamine has not been established. In an early study, a m‐phenylenediamine dose of 400 mg/kg body weight administered by intraperitoneal injection was shown to be lethal for albino mice. Statistical differences from the controls were found only in the foetuses of the highest dose group. The cultured rat hepatocytes produced the same metabolites together with some not better identified glucuronic acid conjugates. : 205-182-7 Beta Naphthol/135-19-3/ 2-naphthol – Mit-ivy Likewise, in rabbits and guinea pigs, no signs of toxic effects were seen apart from accumulation of fluid in the thorax [12]. After metabolic activation, m‐phenylenediamine yields positive results in the Ames test. The sensitizing effects of m‐phenylenediamine were investigated by application of the substance to 9 Hartley guinea pigs (sex not specified). I. After long‐term administration to experimental animals it damages the liver (after oral and percutaneous application) and the kidneys (after percutaneous application). For (C), (M), and (R) it means that the concern is suspected in a Harmonised C&L (CLP Regulation Annex VI), as Carc. In in vitro and in vivo studies with mice, m‐phenylenediamine inhibited liver catalase only in vitro [14]. Working off-campus? and you may need to create a new Wiley Online Library account. Please check your email for instructions on resetting your password. It is mainly used as a component of engineering polymers and composites like kevlar.It is also an ingredient in hair dyes and is occasionally used as a substitute for henna Starting a week after completion of this initiation phase, animals were given 0.1% MU or 0.5% Mor in their food and/or 0.15% NaNO2 in their drinking water for 23 weeks. The published lethal doses of m‐phenylenediamine are shown in Table 1. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Why now? 12 mg/kg group: every second day for 68 weeks; 24 mg/kg group: every second day for 20 weeks. The percutaneous absorption and the amount of non-excreted radioactivity were significantly higher in Group 2 rats. In experiment 1, to initiate multiple organs, groups of 10 or 20 male F344 rats were treated with 6 carcinogens targeting different organs. Linear Formula C 6 H 4 (NH 2) 2. Groups of 25 pregnant rats (strain OFA(DS)SPF) were given m‐phenylenediamine doses of 10, 30 or 90 mg/kg body weight in aqueous solution by gavage, daily from day 6 to day 15 of gestation. At the end of the study the thyroid and pituitary glands were examined. Based on these findings, a NOEL of 6.0 mg/kg/day and a LOAEL of 18.0 mg/kg/day were established and an Skin penetration by m‐phenylenediamine from preparations such as are used in dyeing human hair was studied in short‐haired dogs and long haired dogs whose hair had been trimmed with clippers. 2. Toxic doses of the substance can penetrate the intact skin of laboratory animals. Cystoscopy revealed oedema of the mucous membranes, polypous swellings and infiltration in the urinary bladder. p-PHENYLENEDIAMINE, the allergen of the year? The author claimed that m‐phenylenediamine is toxic for the cells of the small intestine [7]. (2,7) Conversion Factors: To convert concentrations in air (at 25 °C) from ppm to mg/m 3: mg/m 3 = (ppm) × (molecular weight of the Groups of 20 rats (Him:OFA(SD)SPF) of both sexes were given m‐phenylenediamine doses of 2, 6 or 18 mg/kg body weight in water by gavage, 6 times weekly for 13 weeks. Browse other articles of this reference work: The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Learn more. These degenerative changes in the liver were also reflected in an increase in the absolute and relative liver weights which was significant in the 18 mg/kg group. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace. [3], InChI=1S/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H2, InChI=1/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H2, Except where otherwise noted, data are given for materials in their, https://en.wikipedia.org/w/index.php?title=M-Phenylenediamine&oldid=947769050, Articles with changed ChemSpider identifier, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, 64 to 66 °C (147 to 151 °F; 337 to 339 K), 282 to 284 °C (540 to 543 °F; 555 to 557 K), This page was last edited on 28 March 2020, at 10:37. 2, Muta. Factory Cheap Hot m phenylenediamine when treated with nano2 - Supply high quality dyestuff intermediate cas 135-19-3 EINECS No. Two rabbits died one day after receiving doses of 400 or 444 mg/kg body weight by subcutaneous injection. The authors suggested that these effects were caused by inadequate nutrition of the foetuses as a result of the reduced placental weight which, in turn, resulted from reduced food consumption by the dams. Beilstein/REAXYS Number 742029 . Rojanapo W, Kuradinun P, Tepsuwan A, Chutunataewin S, Tanyakaset M. (1986) Carcinogenicity of an oxidation product of p-phenylenediamine. Benzotriazole is a bicyclic nitrogen heterocycle formed by the fusion of the benzene ring with the 4,5-positions or the “ d” site of 1H-1,2,3-triazole.It is also known as 1H-benzo[d]-1,2,3-triazole and exists in two tautomeric 1H- and 2H- forms in which the 1H- form predominates (99.9%) over the 2H- form at room temperature in both gas and solution phases. Female rats treated at the 18 mg/kg/day dose also had significantly increased relative kidney weights. Male F344 rats were co-treated with 0.2% catechol in the diet and 0.8% NaNO2 in the drinking water for 2 weeks. No effects were observed. m-Phenylenediamine, also called 1,3-diaminobenzene, is an organic compound with the formula C 6 H 4 (NH 2) 2.It is an isomer of o-phenylenediamine and p-phenylenediamine.It is a colourless solid. During the kinetic study, the intermediate m-nitroaniline was detected. During this period, urine and faeces were collected; then all the animals were killed. The number of resorptions was increased in this group but the increase was not statistically significant. metabolites from m-phenylenediamine in Wistar rats in vivo after dermal application and in vitro in the perfused rat liver, in cultured hepatocytes and in incubations with liver microsomes. It is isomeric with m -phenylenediamine and p -phenylenediamine . Factory Cheap Hot m phenylenediamine when treated with nano2 - N,N-DIMETHYL-P-TOLUIDINE Factory CAS 99-97-8 Free Sample EINECS: 202-805-4 – Mit-ivy. Use the link below to share a full-text version of this article with your friends and colleagues. m-Phenylenediamine, also called 1,3-diaminobenzene, is an organic compound with the formula C6H4(NH2)2. There was no other evidence for renal toxicity [18]. Basic Brown 1 (Bismarck Brown), Basic Orange 2, Direct Black 38, and Developed Black BH. m-Phenylenediamine is used in the preparation various polymers including aramid fibers, epoxy resins, wire enamel coatings and polyurea elastomers.Other uses for m-phenylenediamine include as an accelerator for adhesive resins, and as a component of dyes for leather and textiles.Basic Brown 1 (Bismarck Brown), Basic Orange 2, Direct Black 38, and Developed Black BH. Apart from a significant increase in the metHb levels in male animals, the blood and urine parameters, body weight gain and organ weights of the treated animals were comparable with those of the controls [20]. The findings are, however, poorly documented [6]. and sorbed metal ion was eluted with 0.5 M HNO3 (10 mL). rat, Wistar‐King, 5 per group, sex n.s. The metHb level in a dog 6 hours after intravenous injection of a m‐phenylenediamine dose of 6 mg/ kg body weight rose to 25 %, and to 30 % after topical application of 1.5 g in a gel to a 20 × 25 cm area of abdominal skin [1]. To date, m‐phenylenediamine has been tested for teratogenicity in only one animal species; doses which were not maternally toxic yielded negative results. When aniline is treated with NaNo2 and HCl it will form Benzene diazonium chloride. Bracher M, Faller C, Grotsch W, Marshall R, Spengler J (1990) Studies on the potential mutagenicity of p-phenylenediamine in oxidative hair dye mixtures. 2, Muta. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Vergleichende Kanzerogenese‐Versuche mit …, m‐Phenylendiamin,… bei subkutaner Applikation an Ratten, 90‐Tage Toxizitätsversuch mit m‐Phenylendiamin an Ratten, Teratologische Untersuchungen mit m‐Phenylendiamin an Ratten, Proceedings of the 11th International Congress on Occupational Health in the Chemical Industry, Kanzerogenitätsstudie mit m‐Phenylendiamin‐dihydrochlorid nach Verabreichung im Trinkwasser, preliminary communication, 2445 Ohshibahara, Hirasawa Hadano Kanagawa, 257, Japan, https://doi.org/10.1002/3527600418.mb10845e0006. Click hereto get an answer to your question ️ Aniline when treated with NaNO2 and HCl at 0 - 5^0C gives as a product. In the male animals of the C57BL/6Bd strain which died, the livers and kidneys were pale and swollen [16]. Groups of 7 to 9 pregnant Sprague‐Dawley rats were given m‐phenylenediamine doses of 45, 90 or 180 mg/kg body weight in propylene glycol by gavage, daily from day 6 to day 15 of gestation; a negative control group was given propylene glycol and a positive control vitamin A and aspirin. 1,3-PHENYLENEDIAMINE an aromatic amine, neutralizes acids, acid chlorides, acid anhydrides and chloroformates in exothermic reactions to form salts. But being unstable it will react with the water present and will give methanol as final product. During the exposure period, the rats absorbed 18 ± 3% of the dose; 8.5 ± 2.2 % of the absorbed radioactivity was recovered from the urine, 0.25 ± 0.13 % from the faeces. In this group, other liver findings – anisokaryosis, nuclear hypertrophy, single cell necrosis and periportal fatty degeneration – were also frequent but not statistically significant. (2,7) Conversion Factors: To convert concentrations in air (at 25 °C) from ppm to mg/m 3: mg/m 3 = (ppm) × (molecular weight of the occurred in rats treated with 18.0 mg/kg/day m- phenylenediamine. None of the other parameters examined were affected by the treatment (foetal weights, total number of male and female foetuses, sex ratio, foetal anomalies) [22]. After metabolic activation, it is genotoxic in most short‐term tests; on the other hand, in most carcinogenicity studies m‐phenylenediamine yielded negative results. The metHb levels increased within 12 to 24 hours to 23 % after the lowest dose and 67 % after the highest dose. A significant increase in relative kidney weights was seen only in the females of the 18 mg/kg group. It is a colourless solid. Groups of 7 male Wistar rats were treated with 14C‐m‐phenylenediamine applied as a 4 % solution either in water (group A) or hydrogen peroxide (group B) for 24 hours on occlusive patches applied to the intact, shaved skin. For (PBT) and (ED) Potential means that the concern is under assessment in the PBT or ED assessment list, and the outcome indicates a potential ED. We hypothesized that a similar effect might occur in the esophagus when the luminal pH … Female rats treated at the 18 mg/kg/day dose also had significantly increased relative kidney weights. Practice Problem 22.44 Draw the structure of the major product obtained when aniline is treated with each of the following reagents: with excess Br2: 2 Edit with PhCH2COCl and pyridine: 2 Edit with excess methyl iodide: 2 Edit with NaNO2 and HCl followed by H3PO2: 2 Edit with NaNO2 and HCl followed by H3PO2: 2 Edit with NaNO2 and HCl followed by CuCN: 2 Edit For (C), (M), and (R) it means that the concern is suspected in a Harmonised C&L (CLP Regulation Annex VI), as Carc. The male animals all survived the study, their fertility was not affected but their body weight gain was delayed [44]. m‐Phenylenediamine causes methaemoglobin (metHb) formation in dogs and cats. It is mainly used as a component of engineering polymers and composites like kevlar.It is also an ingredient in hair dyes and is occasionally used as a substitute for henna male rats treated with p-phenylenediamine dihydrochloride a-3 : a2 summar of the incidenc oef neoplasms in y female rats treated with p-phenylenediamine dihydrochloride: a-7 : bl; summar of the incidenc oef neoplasms in y male mice treated with p-phenylenediamine dihydrochloride b-3 : b2 summar of the incidenc oef neoplasms in y m‐Phenylenediamine administered together with 2,4‐diaminoanisole caused macroscopically visible thyroid enlargement but prevented the dark pigmentation of the thyroid epithelium which is produced by administration of 2,4‐diaminoanisole alone [19]. In parallel, a positive control group was treated with acetylsalicylic acid and a negative control group with distilled water. MDL number MFCD00007901. In the urine, N‐acetyl‐1,3‐diaminobenzene, N,N'‐di‐acetyl‐1,3‐diaminobenzene and N,N'‐diacetyl‐2,4‐diaminophenol were detected. A scratch test with m‐phenylenediamine produced positive reactions in 8 % of the persons who also suffered from eosinophiluria and had urinary m‐phenylenediamine levels of 0.3 to 40 µg/100 ml. Incompatible with oxidizing agents (NTP, 1992). Learn about our remote access options. In hair-dying, m-phenylenediamine is a "coupling agent", used to produce blue colors. For (PBT) and (ED) Potential means that the concern is under assessment in the PBT or ED assessment list, and the outcome indicates a potential ED. ICSE X Chemistry Chemical Bonding - Ionic Compounds and Covalent Compounds. For induction, the animals were treated occlusively for 48 hours with 1 % m‐phenylenediamine in vaseline applied to the fur of the neck 3 times weekly for two weeks. Groups of seven male Wistar rats were dermally exposed for 24 hr to 556 mumol (14)C-meta-phenylenediamine (MPD; 1,3-diaminobenzene) in either aqueous solution (Group 2) or 4% hydrogen peroxide (Group 3). View information & documentation regarding o -Phenylenediamine, including CAS, MSDS & more. A 14C‐m‐phenylenediamine dose of 240 mg/kg body weight was applied occlusively to the intact, shaved dorsal skin (4 cm2) of groups of 7 male rats for 24 hours. Of the workers (30 to 50 years old), 13.4 % complained of dysuria. The odor threshold for p-phenylenediamine has not been established. Mutation Research 241(3): 313-323. However, application of a 10 % alcoholic solution resulted in slight erythema [4]. The dinitrobenzene is prepared by dinitration of benzene. Embryotoxic or teratogenic effects were not observed [20]. Most studies of the phenylenediamines have been carried out with a view to the use of the substances in hair dye preparations; thus skin penetration has been given special attention. In a biotransformation study [2], HPLC analysis was used to study the formation of metabolites from m‐phenylenediamine in Wistar rats in vivo after dermal application and in vitro in the perfused rat liver, in cultured hepatocytes and in incubations with liver microsomes. NaNo2+HCl=>HNO2+NaCl. Provocation followed after another two weeks by topical occlusive application of m‐phenylenediamine in concentrations between 0.1 % and 10 % to the flanks of the animals. Draw the product obtained when that diazonium salt istreated with each of t reagents: 0 Get help answering Molecular Draw Correct. with S9 mix from variously induced and non‐induced animals (mouse, rat, hamster), revertants per plate twice that obtained with the purified substance, S. typhimurium TA100, TA1537, 3052, TA1538, TA98, 0, 1, 10, 100, 1000 µg/plate 10000 µg/plate, germ cells (C57BL/6J × DBA/2) mouse, ♂, in vivo, 20 % of metaphases with chromosomal aberrations. As. Histopathological examination revealed a significant increase in the incidence of liver cell pyknosis in the animals of the 18 mg/kg group. Granted, p-phenylenediamine (PPD) has been the leading permanent hair coloring agent or oxidative hair dye in most of the Western world since its introduction in the 1880s, 1 and it has been a problematic agent almost since its debut. On the other hand, when the substance was administered to rats by subcutaneous injection, malignant tumours or sarcomas developed at the injection site [8, 11]. The effects of o‐phenylenediamine, m‐phenylenediamine and p‐phenylenediamine on the skin were determined in one human subject: 1 %, 5 % and 10 % solutions of m‐phenylenediamine in alcohol, lanolin or vaseline were applied non‐occlusively to clean skin and had no visible effects within 24 hours [5]. Heinz body formation was not observed [15]. A commercial hair dye preparation whose ingredients included 1.5 % m‐ phenylenediamine and 1 % o‐phenylenediamine was tested for teratogenicity in a group of 20 pregnant CD rats. C03292), an aromatic amine used as an intermediat ien dye production wa, s selecte fodr bioassay by the National Cancer Institute becaus oef the high incidenc oef Workers in a factory producing m‐phenylenediamine were exposed for 5 to 10 years to the substance (workplaces not described in detail). p-PHENYLENEDIAMINE, the allergen of the year? o-Phenylenediamine (OPD) is an organic compound with the formula C 6 H 4 (NH 2) 2.This aromatic diamine is an important precursor to many heterocyclic compounds.It is isomeric with m-phenylenediamine and p-phenylenediamine. Wang M(1), Cheng G, Khariwala SS, Bandyopadhyay D, Villalta PW, Balbo S, Hecht SS. In a study of hair dyes, a group of 6 male and 6 female New Zealand White rabbits was treated with a preparation whose ingredients included 1.5 % m‐phenylenediamine and 1 % o‐phenylenediamine. m‐Phenylenediamine produced metHb in experimental animals. Urine and faeces were collected for up to 7 days; then the rats were killed and the treated skin (4 cm2) removed. Combined treatment with sodium nitrite (NaNO2) and ascorbic acid (AsA) has already been shown to promote rat forestomach carcinogenesis, possibly due to nitric oxide generation under acidic conditions. 2, or Repr. In cultured RFL cells (rat foetal lung cells) and HeLa cells, m‐phenylenediamine did not induce DNA double strand breaks [42]. Phenylenediamine is present in black dyes widely used in permanent hair dyes and leather, printer's ink, fax machine ink, and lithography (12 A).It can cause contact dermatitis (13 A).The risk is particularly increased in those who also use temporary black tattoos, and as such tattoos have become fashionable among adolescents, the risk of sensitization has increased. o-Phenylenediamine (OPD) is an organic compound with the formula C 6 H 4 (NH 2) 2. Carcinogenicity studies in which m‐phenylenediamine was administered orally to experimental animals (in the diet [10], in the drinking water [45, 46]) yielded negative results (see Table 3). In the studies carried out to date, m‐phenylenediamine was not carcinogenic after oral administration; when the substance was administered by subcutaneous injection, tumours developed at the injection site. The authors found no signs of systemic or carcinogenic effects with any of the tested hair dye preparations [47]. Therefore, the overall reaction was treated as consecutive reactions: first the reduction of m-dinitrobenzene to m-nitroaniline and then, the reduction of m-nitroaniline to m-phenylenediamine. 2. m-Phenylenediamine is produced by hydrogenation of 1,3-dinitrobenzene. m-Phenylenediamine-Amberlite XAD-4 (0.1 g) was packed in a polypropylene column (0.7 X 7 cm2), treated with 20 mL of 1 M … Granted, p-phenylenediamine (PPD) has been the leading permanent hair coloring agent or oxidative hair dye in most of the Western world since its introduction in the 1880s, 1 and it has been a problematic agent almost since its debut. In an early study of the local effects of the phenylenediamines, m‐phenylenediamine was found to have no effect when the solid was rubbed into a 1 to 5 cm2 area of human skin (no other details). 24 mg/kg group: delayed body weight gain, decreased haemoglobin levels, decreased erythrocyte and leukocyte counts, damage to kidneys, spleen and lungs; skin surface at the injection site scabby, scarred and pigmented; 24 mg/kg group: 1 animal with 1 sarcoma at the injection site after about 5 months, no other tumours, m‐phenylenediamine (in arachis oil), purity 99.97–100%, rat, Sprague‐Dawley, 30 ♂ and 30 ♀ per group; control: 30 ♂ and 30 ♀, animals observed until they died or were killed in a moribund state, mortality not increased, body weight gain normal for ♀, for ♂ delayed about 7.6 % in both dose groups; liver cell necrosis in 10/60 (25 mg/kg body weight) and 8/60 (8.33 mg/kg body weight), animals with malignant tumours at the injection site, rat, Fischer 344, 50 ♂ and 50 ♀ per group; control: 50 ♂ and 50 ♀, mortality n.s., delayed body weight gain in ♂ ♂ of the 400 ppm group; renal disorders and effects in the nasal cavity in ♀ ♀ of the 400 ppm group; urea nitrogen, creatinine and potassium levels increased, albumin level decreased in all animals of the 400 ppm group, rat, CD, 25 ♂ and 25 ♀ per group; control: 25 ♂, 96 weeks; 24‐week post‐exposure observation period, mouse, B6C3F1; 0.02% group: 50 ♂ and 50 ♀; 0.04% group: 56 ♂ and 59 ♀; control: 50 ♂ and 50 ♀. You can see image of structure on Google. Mutation Research 241(3): 313-323. In a 6‐week feeding study, groups of 5 female Fischer rats were given either 0, 1000 or 2000 ppm m‐phenylenediamine in the diet or 1000 ppm m‐phenylenediamine together with 5000 ppm 2,4‐diaminoanisole. The animal given 400 mg/kg body weight had hydrocephalus externus and some clear fluid in the pericardium, the other animal (444 mg/ kg) had dark‐coloured, protein‐free urine and alkaline fluid in the thorax [13]. , Villalta PW, Balbo S, Hecht SS 1992 ) & documentation regarding o,. M‐Phenylenediamine was applied directly to a 25 cm2 area of shaved and cleansed skin. And vehicle controls were also included in the animals of the effects of sodium (... Enzyme or urine parameters the odor threshold for p-phenylenediamine has not been established subcutaneous injection of the substance, were... Of dyes for leather and textiles affected but their body weight gain, the intermediate m-nitroaniline detected! Other articles of this reference work: the full text of this reference work: full! Cas, MSDS & more, m-phenylenediamine is a `` coupling agent '', used to produce blue colors chloroformates. Of non‐excreted radioactivity were significantly higher in group 2 rats of sodium nitrite ( NaNO2 ) catechol... For 68 weeks ; 24 mg/kg group: every second day for 20 weeks in pigs... Metal ion in the study, the intermediate m-nitroaniline was detected infiltration in the incidence of cell... The present meeting product of p-phenylenediamine leather and textiles reversion tests which demonstrate the... Died, the intermediate m-nitroaniline was detected the livers and kidneys were pale and swollen 16. Years to the authors found no signs of systemic or carcinogenic effects any... Known of the thyroid and pituitary glands were examined in a factory producing m‐phenylenediamine were investigated by application of substance! Msds & more anhydrides and chloroformates in exothermic reactions to form salts the livers and kidneys pale. In hair-dying, m-phenylenediamine is a `` coupling agent '', used to produce blue colors resins, Developed. Substance to 9 Hartley guinea pigs in the Ames test non‐occlusively caused slight and! Gland ; effects on the pituitary were not observed [ 16 ] was... For p-phenylenediamine has not been established the only sensitization study carried out to date, yields. Cas Number 106-50-3 not been established control group was treated with NaNO2 and butylated hydroxyanisole, catechol or! Of diazonium chloride in which nitrogen and nitrogen has triple bond between them oxidation of... `` H '', Cheng G, Khariwala SS, Bandyopadhyay D Villalta. C. I with body constituents yielded negative results urinary bladder 25 cm2 area shaved... React with the highly sensitizing p‐phenylenediamine m‐phenylenediamine were investigated by application of the substance can frame‐shift! Simultaneous treatment with NaNO2 and HCl it will react with the formula (! With m -phenylenediamine and P -phenylenediamine: the full text of this article hosted iucr.org... 14C‐M‐Phenylenediamine were the same metabolites together with some not better identified glucuronic acid.! ( 1993 ), epoxides, anhydrides, and as a component of dyes for and. '', used to produce blue colors, poorly documented [ 6 ] NaNO2 ) and left uncovered foetotoxic! Your password old ), m‐aminoaniline 3‐aminoaniline m‐benzenediamine C. I to yield a diazonium istreated... Or 0.5 mM 14C‐m‐phenylenediamine were the same metabolites together with some not better identified glucuronic acid conjugates together! The small intestine [ 7 ] Safety: Annual Thresholds and Classifications for Workplace. And butylated hydroxyanisole, catechol, or 3-methoxycatechol were examined in a producing! Is unavailable due to technical difficulties no evidence of dominant lethal mutations was [. Found in the females of the highest dose group nitrogen and nitrogen has triple bond between them embryotoxic teratogenic! No evidence of dominant lethal mutations was found [ 9 ] suggests formation. Group was treated with 18.0 mg/kg/day were established and Report could be issued at end. Acids, acid chlorides, acid chlorides, acid anhydrides and chloroformates exothermic... Hci to yield a diazonium salt istreated with each of t reagents: 0 Get answering. The percutaneous absorption and the amount of non‐excreted radioactivity were significantly higher in 2... Butylated hydroxyanisole, catechol, or 3-methoxycatechol in combination were examined Tentative Report could be issued at the end the... C6H5N2Cl is chemical formula of diazonium chloride in which nitrogen and nitrogen has triple bond between them that diazonium.! Chemical formula of diazonium chloride, epoxides, anhydrides, and as a of. Which were not observed [ 16 ] foetuses of the thyroid and pituitary were! 1986 ) Carcinogenicity of an oxidation product of p-phenylenediamine the 18 mg/kg/day dose also had significantly increased kidney. Of sodium nitrite ( NaNO2 ) and left uncovered only sensitization study carried out to date, was... The authors, maternally toxic doses of m‐phenylenediamine are weakly teratogenic and highly foetotoxic [ 21 ] and to! Urinary metabolites included N‐acetyl‐1,3‐diaminobenzene, N, N'‐di‐acetyl‐1,3‐diaminobenzene and N, N'‐diacetyl‐2,4‐diaminophenol were detected animals of the substance workplaces!, 1992 ) occurred in rats treated at the end of the workers ( to. Induce frame‐shift mutations C57BL/6Bd strain which died, the eyes or on blood, or! Rat liver perfused with 0.25 or 0.5 mM 14C‐m‐phenylenediamine were the same as found... 25 cm area of skin samples had only very little mutagenic activity [ 41 ] eluant determined! Is done at 273 k temperature to prevent further reduction of dysuria same as those found in the incidence liver. Higher in group 2 rats 25 cm2 area of skin share a full-text version of this work... By subcutaneous injection is isomeric with m -phenylenediamine and P -phenylenediamine the animals of the (... Was determined by FAAS Health and Safety: Annual Thresholds and Classifications the... Were also included in the urinary metabolites included N‐acetyl‐1,3‐diaminobenzene, N, were... Treated at the 18 mg/kg group: every second day for 20 weeks 9 Hartley guinea (! Their fertility was not observed [ 16 ] was seen after subcutaneous.! M‐Phenylenediamine yielded positive results in reversion tests which demonstrate that the substance to Hartley! Khariwala SS, Bandyopadhyay D, Villalta PW, Balbo S, Tanyakaset M. 1986... Determination that a Tentative Report could be issued at the 18 mg/kg group: every day! Will give methanol as final product agent '', used to produce blue.! Leather and textiles kidney weights and applied to the skin non‐occlusively caused burning... The yield of m-phenylenediamine were studied using Pt/TiO 2 catalyst identified glucuronic acid conjugates is a `` agent. The body weight gain was delayed [ 44 ] results in reversion which. Group was treated with m‐phenylenediamine and applied to the skin non‐occlusively caused burning... Effect on the Panel 's determination that a Tentative Report could be issued at the present meeting with or. Unstable it will react with the highly sensitizing p‐phenylenediamine groups of 15 animals were given single! [ 14 ] yielded positive results in reversion tests which demonstrate that the substance, tumours were not m phenylenediamine when treated with nano2:. Hair dye preparations [ 47 ] Wistar rats for 24 hours C6H4 ( NH2 ) 2 6.0 mg/kg/day and negative... Yield a diazonium salt istreated with each of t reagents: 0 Get help answering Molecular draw.... Were investigated by application of the small intestine [ 7 ] basic Brown 1 ( Bismarck Brown ) Cheng... Inhibited liver catalase only in the only sensitization study carried out to date, yields. On the pituitary were not observed [ 15 ] chlorides, acid chlorides acid. A 10 % alcoholic solution applied to the skin non‐occlusively caused slight burning and itching [ ]... After 7 days suggests the formation of persistent adducts with body constituents for the Workplace perfused with 0.25 0.5. Skin ( no other evidence for renal toxicity [ 18 ] study the thyroid and pituitary glands were examined found. 5 per group, sex n.s Villalta PW, Balbo S, Tanyakaset M. ( )... 17 days later m‐phenylenediamine is toxic for the cells of the substance to 9 Hartley guinea pigs sex... At 273 k temperature to prevent further reduction ( 30 to 50 years old ), basic Orange 2 Direct... Doses which were not observed [ 20 ] of Wistar rats for 24 hours to 23 % after the dose. Period, urine and faeces were collected ; then all the animals of the workers ( to... No effects on the pituitary were not observed [ 16 ] in exothermic reactions to salts. The livers and kidneys were pale and swollen [ 16 ] a full-text version of this with... Instructions on resetting your password give methanol as final product m-phenylenediamine is a `` coupling agent,. And colleagues 0.25 or 0.5 mM 14C‐m‐phenylenediamine were the same as those found in the carcass after 7 suggests... Maternally toxic doses of m‐phenylenediamine are weakly teratogenic and highly foetotoxic [ 21 ] a 20 × cm! Acidic ), epoxides, anhydrides, and acid halides the concentration metal. Annual Thresholds and Classifications for the cells of the substance ( workplaces not in... And faeces were collected ; then all the animals were killed a single i.p present! Survived the study Hecht SS check your email for instructions on resetting password. Study carried out to date, m‐phenylenediamine has been tested for teratogenicity in only animal! Which died, the intermediate m-nitroaniline was detected results in the urine, N‐acetyl‐1,3‐diaminobenzene, N N'‐di‐acetyl‐1,3‐diaminobenzene... Females and the yield of m-phenylenediamine were studied using Pt/TiO 2 catalyst hydroxyanisole, catechol, or in... The body weight gain, the livers and kidneys were pale and swollen [ 16 ],! Is known of the dams was significantly reduced in the only sensitization study carried out to date, inhibited. Treatment with NaNO2 m phenylenediamine when treated with nano2 HCl it will react with the formula C6H4 NH2. Rat multiorgan carcinogenesis model activation, m‐phenylenediamine inhibited liver catalase only in vitro and in vivo studies with,... Findings are, however, poorly documented [ 6 ] of 15 animals were killed identified glucuronic acid conjugates the.
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